Publications from the Center 2016

Jalland C, Scheffler K, Benestad S, Moldal T, Ersdal C, Gunnes G, Suganthan R, Bjørås M, Tranulis M. Neil3 induced neurogenesis protects against prion disease during the clinical phase. Sci Reports. 6:37844

Dahl JA, Jung I, Aanes H, Greggains GD, Mana A, Lerdrup M, Li G, Kuan S, Li B, Lee AY, Preissl S, Jermstad I, Haugen MH, Suganthan R, Bjørås M, Hansen K, Dalen KT, Fedorcsak P, Ren B, Klungland A. Broad histone H3K4me3 domains in mouse oocytes modulate maternal to zygotic transition.
Nature, Sep 14;537(7621):548-552

Palibrk V, Suganthan R, Scheffler K, Wang W, Bjørås M# and Bøe SO. PML# regulates neuroprotective innate immunity and neuroblast commitment in a hypoxia ischemic encephalopathy model. Cell Death and Disease. 2016. 7(7):e2320

Karlsen TA, de Souza G, Ødegaard B, Engebretsen L, Brinchmann JE.
MicroRNA-140 inhibits inflammation and stimulates chondrogenesis in a model of IL1β-induced osteoarthritis. Mol Ther Nucleic Acids. 2016 Oct 11;5(10) :e373. doi: 10.1038/mtna.2016.64.

Costantini M, Idaszek J, Szöke K, Jaroszewicz J, Dentini M, Barbetta A, Brinchmann JE, Święszkowski W. 3D bioprinting of BM-MSCs-loaded ECM biomimetic hydrogels for in vitro neocartilage formation. Biofabrication. 2016 Jul 19;8(3):035002. doi: 10.1088/1758-5090/8/3/035002.

Behnan J, Stangeland B, Langella T, Finocchiaro G, Murrell W, Brinchmann JE. Ultrasonic Surgical Aspirate is a Reliable Source For Culturing Glioblastoma Stem Cells. Sci Rep. 2016 Sep 8;6:32788. doi: 10.1038/srep32788.

Behnan J, Stangeland B, Hosainey SA, Joel M, Olsen TK, Micci F, Glover JC, Isakson P, Brinchmann JE. Differential propagation of stroma and cancer stem cells dictates tumorigenesis and multipotency. Oncogene. 2016 Jun 27. doi: 10.1038/onc.2016.230.

Aae TF, Randsborg PH, Breen AB, Visnes H, Vindfeld S, Sivertsen EA, Løken S, Brinchmann J, Hanvold HA, Årøen A. Norwegican Cartilage Project - a study protocol for a double-blinded randomized controlled trial comparing arthroscopic microfracture with arthroscopic debridement in focal cartilage defects in the knee. BMC Musculoskelet Disord. 2016 Jul 16;17:292. doi: 10.1186/s12891-016-1156-y.

Randsborg PH, Brinchmann J, Løken S, Hanvold HA, Aae TF, Årøen A. Focal cartilage defects in the knee - a randomized controlled trial comparing autologous chondrocyte implantation with arthroscopic debridement. BMC Musculoskelet Disord. 2016 Mar 8;17:117. doi: 10.1186/s12891-016-0969-z.

Szöke K, Reinisch A, Østrup E, Reinholt FP, Brinchmann JE. Autologous cell sources in therapeutic vasculogenesis: In vitro and in vivo comparison of endothelial colony-forming cells from peripheral blood and endothelial cells isolated from adipose tissue. Cytotherapy. 2016 Feb;18(2):242-52. doi: 10.1016/j.jcyt.2015.10.009.

Karlsen TA, Jakobsen RB, Brinchmann JE. Early molecular events during in vitro chondrogenesis. In The Biology and Therapeutic Application of Mesenchymal Cells (ed K. Atkinson), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118907474.ch14

Legartová S, Sehnalová P, Malyšková B, Küntziger T, Collas P, Cmarko D, Raška I, Sorokin DV, Kozubek S, Bártová E J, Localized Movement and Levels of 53BP1 Protein Are Changed by γ-irradiation in PML Deficient Cells. Cell Biochem. 2016 Nov;117(11):2583-96. doi: 10.1002/jcb.25551. PMID:27526954

Lindstad T, Qu S, Sikkeland J, Jin Y, Kristian A, Mælandsmo GM, Collas P, Saatcioglu F. STAMP2 is required for human adipose-derived stem cell differentiation and adipocyte-facilitated prostate cancer growth in vivo. Oncotarget. 2016 Aug 9. doi: 10.18632/oncotarget.11131. PMID:27517316

Vanhove J, Pistoni M, Welters M, Eggermont K, Vanslembrouck V, Helsen N, Boon R, Najimi M, Sokal E, Collas P, Voncken JW, Verfaillie CM. H3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in hESC-Derived Hepatocytes In Vitro..Stem Cell Reports. 2016 Aug 9;7(2):192-206. doi: 10.1016/j.stemcr.2016.06.013. PMID:27477635

Oldenburg AR, Collas P. Mapping Nuclear Lamin-Genome Interactions by Chromatin Immunoprecipitation of Nuclear Lamins. Methods Mol Biol. 2016;1411:315-24. doi: 10.1007/978-1-4939-3530-7_20. PMID: 27147051

Sekelja M, Paulsen J, Collas P. 4D nucleomes in single cells: what can computational modeling reveal about spatial chromatin conformation? Genome Biol. 2016 Apr 7;17:54. doi: 10.1186/s13059-016-0923-2. Review. PMID:27052789

Buemo CP, Gambini A, Moro LN, Hiriart MI, Fernández-Martín R, Collas P, Salamone DF. Embryo Aggregation in Pig Improves Cloning Efficiency and Embryo Quality. PLoS One. 2016 Feb 19;11(2):e0146390. doi:10.1371/journal.pone.0146390. PMID:26894831

Marstad A, Landsverk OJ, Strømme O, Otterlei M, Collas P, Sundan A, Brede G. A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis. FEBS J. 2016 Feb;283(4):757-70. doi: 10.1111/febs.13630. PMID: 6683827

Chawla RS, Züchner M, Mastrangelopoulou M, Lambert FM, Glover JC, Boulland JL. Cellular reactions and compensatory tissue re-organization during spontaneous recovery after spinal cord injury in neonatal mice. Dev Neurobiol. 2016 Dec 29. doi: 10.1002/dneu.22479. PMID: 28033684

Züchner M, Glover JC, Boulland JL.
A Neonatal Mouse Spinal Cord Compression Injury Model.
J Vis Exp. 2016 Mar 27;(109):e53498. doi: 10.3791/53498. PMID: 27078037

Bjørnstad S, Samara A, Erichsen A, Paulsen RE, Glover JC, Roald B.Hampered Lung Maturation in Methimazole-Induced Hypothyroidism in Fetal Chicken: Morphological and Molecular Correlates to Human Fetal Development. Neonatology. 2016;110(2):83-92. doi: 10.1159/000444656. PMID: 27070722

Falk A, Heine VM, Harwood AJ, Sullivan PF, Peitz M, Brüstle O, Shen S, Sun YM, Glover JC, Posthuma D, Djurovic S. Modeling psychiatric disorders: from genomic findings to cellular phenotypes.Mol Psychiatry. 2016 Sep;21(9):1321. doi: 10.1038/mp.2016.100. PMID: 27324182

Lambert FM, Bras H, Cardoit L, Vinay L, Coulon P, Glover JC.
Early postnatal maturation in vestibulospinal pathways involved in neck and forelimb motor control.
Dev Neurobiol. 2016 Oct;76(10):1061-77. doi: 10.1002/dneu.22375. PMID:26724676

Sivertsen MS, Perreault MC, Glover JC.
Pontine reticulospinal projections in the neonatal mouse: Internal organization and axon trajectories. J Comp Neurol. 2016 Apr 15;524(6):1270-91. doi: 10.1002/cne.23904. PMID:26400815

Liu F, Clark W, Luo G, Wang X, Fu Y, Wei J, Wang X, Hao Z, Dai Q, Zheng G, Ma H, Han D, Evans M, Klungland A, Pan T, He C.
ALKBH1-Mediated tRNA Demethylation Regulates Translation
Cell. 2016 Dec 15;167(7):1897. doi: 10.1016/j.cell.2016.11.045. PMID: 27984735

Klungland A, Robertson AB.
Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine.
Free Radic Biol Med. 2016 Nov 24. pii: S0891-5849(16)31072-3. doi: 10.1016/j.freeradbiomed.2016.11.038. PMID: 27890639

Vindedal GF, Thoren AE, Jensen V, Klungland A, Zhang Y, Holtzman MJ, Ottersen OP, Nagelhus EA. Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation. Mol Cell Neurosci. 2016 Dec;77:47-52. doi: 10.1016/j.mcn.2016.10.004. PMID: 27751903

Liu F, Clark W, Luo G, Wang X, Fu Y, Wei J, Wang X, Hao Z, Dai Q, Zheng G, Ma H, Han D, Evans M, Klungland A, Pan T, He C.
ALKBH1-Mediated tRNA Demethylation Regulates Translation. Cell. 2016 Oct 20;167(3):816-828.e16. doi: 10.1016/j.cell.2016.09.038. PMID: 27745969

Lauritzen KH, Hasan-Olive MM, Regnell CE, Kleppa L, Scheibye-Knudsen M, Gjedde A, Klungland A, Bohr VA, Storm-Mathisen J, Bergersen LH.
A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain. Neurobiol Aging. 2016 Dec;48:34-47. doi: 10.1016/j.neurobiolaging.2016.08.005. PMID: 27639119

Møllersen L, Moldestad O, Rowe AD, Bjølgerud A, Holm I, Tveterås L, Klungland A, Retterstøl L. Effects of Anthocyanins on CAG Repeat Instability and Behaviour in Huntington's Disease R6/1 Mice.
PLoS Curr. 2016 Jul 5;8. pii: ecurrents.hd.58d04209ab6d5de0844db7ef5628ff67. doi: 10.1371/currents.hd.58d04209ab6d5de0844db7ef5628ff67. PMID: 27540492

A Alemu E, He C, Klungland A.
ALKBHs-facilitated RNA modifications and de-modifications. DNA Repair (Amst). 2016 Aug;44:87-91. doi: 10.1016/j.dnarep.2016.05.026. Review. PMID: 27237585

Weber AR, Krawczyk C, Robertson AB, Kuśnierczyk A, Vågbø CB, Schuermann D, Klungland A, Schär P.Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism.
Nat Commun. 2016 Mar 2;7:10806. doi: 10.1038/ncomms10806. PMID: 26932196

Landfors M, Nakken S, Fusser M, Dahl JA, Klungland A, Fedorcsak P.
Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies an infertility-associated variant and two missense mutations. Fertil Steril. 2016 May;105(5):1170-1179.e5. doi: 10.1016/j.fertnstert.2016.01.002. PMID: 26820768

Ougland R, Jonson I, Moen MN, Nesse G, Asker G, Klungland A, Larsen E.
Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells.
Cell Physiol Biochem. 2016;38(1):173-84. doi: 10.1159/000438619. PMID: 26765775

Klungland A, Yang YG. Endogenous DNA Damage and Repair Enzymes: -A short summary of the scientific achievements of Tomas Lindahl, Nobel Laureate in Chemistry 2015. Genomics Proteomics Bioinformatics. 2016 Jun;14(3):122-5. doi: 10.1016/j.gpb.2015.11.001. PMID: 26689322

Mi S, Klungland A, Yang YG.
Base-excision repair and beyond --A short summary attributed to scientific achievements of Tomas Lindahl, Nobel Prize Laureate in Chemistry 2015. Sci China Life Sci. 2016 Jan;59(1):89-92. doi: 10.1007/s11427-015-4983-4. PMID: 26676642

Kyte JA, Gaudernack G, Faane A, Lislerud K, Inderberg EM, Brunsvig P, Aamdal S, Kvalheim G, Wälchli S, Pule M.
T-helper cell receptors from long-term survivors after telomerase cancer vaccination for use in adoptive cell therapy. Oncoimmunology. 2016 Oct 24;5(12):e1249090. doi: 10.1080/2162402X.2016.1249090. PMID: 28123886

Kyte JA, Aamdal S, Dueland S, Sæbøe-Larsen S, Inderberg EM, Madsbu UE, Skovlund E, Gaudernack G, Kvalheim G.
Immune response and long-term clinical outcome in advanced melanoma patients vaccinated with tumor-mRNA-transfected dendritic cells. Oncoimmunology. 2016 Oct 18;5(11):e1232237. doi: 10.1080/2162402X.2016.1232237. PMID: 27999747

Midttun Ø, McCann A, Aarseth O, Krokeide M, Kvalheim G, Meyer K, Ueland PM. Combined Measurement of 6 Fat-Soluble Vitamins and 26 Water-Soluble Functional Vitamin Markers and Amino Acids in 50 μL of Serum or Plasma by High-Throughput Mass Spectrometry. Anal Chem. 2016 Nov 1;88(21):10427-10436. PMID: 27715010

Li X, Zhong Y, Lu J, Axcrona K, Eide L, Syljuåsen RG, Peng Q, Wang J, Zhang H, Goscinski MA, Kvalheim G, Nesland JM, Suo Z.
MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features. Oncotarget. 2016 Jun 28;7(26):40297-40313. doi: 10.18632/oncotarget.9610. Erratum in: Oncotarget. 2017 Jan 24;8(4):7208-7213. PMID: 27248169

Sioud M, Nyakas M, Sæbøe-Larssen S, Mobergslien A, Aamdal S, Kvalheim G. Diversification of Antitumour Immunity in a Patient with Metastatic Melanoma Treated with Ipilimumab and an IDO-Silenced Dendritic Cell Vaccine.
Case Rep Med. 2016;2016:9639585. doi: 10.1155/2016/9639585. PMID: 27504122

Fayzullin A, Tuvnes FA, Skjellegrind HK, Behnan J, Mughal AA, Langmoen IA, Vik-Mo EO. Time-lapse phenotyping of invasive glioma cells ex vivo reveals subtype-specific movement patterns guided by tumor core signaling. Exp Cell Res. 2016 Dec 10;349(2):199-213. doi: 10.1016/j.yexcr.2016.08.001. PubMed PMID: 27515001.

Skjellegrind HK, Fayzullin A, Johnsen EO, Eide L, Langmoen IA, Moe MC, Vik-Mo EO. Short-Term Differentiation of Glioblastoma Stem Cells Induces Hypoxia Tolerance. Neurochem Res. 2016 Jul;41(7):1545-58. doi: 10.1007/s11064-016-1868-2. PubMed PMID: 26915110; PubMed Central PMCID: PMC4893075.

Kierulf-Vieira KS, Sandberg CJ, Grieg Z, Günther CC, Langmoen IA, Vik-Mo EO. Wnt inhibition is dysregulated in gliomas and its re-establishment inhibits proliferation and tumor sphere formation. Exp Cell Res. 2016 Jan 1;340(1):53-61. doi: 10.1016/j.yexcr.2015.12.010. PubMed PMID: 26712519.

Hytti M, Szabó D, Piippo N, Korhonen E, Honkakoski P, Kaarniranta K, Petrovski
G, Kauppinen A. Two dietary polyphenols, fisetin and luteolin, reduce
inflammation but augment DNA damage-induced toxicity in human RPE cells. J Nutr
Biochem. 2017 Jan 9;42:37-42. doi: 10.1016/j.jnutbio.2016.12.014. PubMed PMID: 28113103.

Nagymihály R, Veréb Z, Albert R, Sidney L, Dua H, Hopkinson A, Petrovski G.
Cultivation and characterisation of the surface markers and carbohydrate profile
of human corneal endothelial cells. Clin Exp Ophthalmol. 2016 Dec 29. doi:
10.1111/ceo.12903. PubMed PMID: 28032398.

Lumi X, Lužnik Z, Petrovski G, Petrovski BÉ, Hawlina M. Anatomical success
rate of pars plana vitrectomy for treatment of complex rhegmatogenous retinal
detachment. BMC Ophthalmol. 2016 Dec 9;16(1):216. PubMed PMID: 27938367; PubMed Central PMCID: PMC5148843.

Recek N, Andjelić S, Hojnik N, Filipič G, Lazović S, Vesel A, Primc G, Mozetič
M, Hawlina M, Petrovski G, Cvelbar U. Microplasma Induced Cell Morphological
Changes and Apoptosis of Ex Vivo Cultured Human Anterior Lens Epithelial Cells -
Relevance to Capsular Opacification. PLoS One. 2016 Nov 10;11(11):e0165883. doi:
10.1371/journal.pone.0165883. PubMed PMID: 27832099; PubMed Central PMCID:

Szatmári-Tóth M, Kristóf E, Veréb Z, Akhtar S, Facskó A, Fésüs L, Kauppinen A,
Kaarniranta K, Petrovski G. Clearance of autophagy-associated dying retinal
pigment epithelial cells - a possible source for inflammation in age-related
macular degeneration. Cell Death Dis. 2016 Sep 8;7(9):e2367. doi:
10.1038/cddis.2016.133. PubMed PMID: 27607582; PubMed Central PMCID: PMC5059849.

Gáspár R, Pipicz M, Hawchar F, Kovács D, Djirackor L, Görbe A, Varga ZV,
Kiricsi M, Petrovski G, Gácser A, Csonka C, Csont T. The cytoprotective effect of
biglycan core protein involves Toll-like receptor 4 signaling in cardiomyocytes.
J Mol Cell Cardiol. 2016 Oct;99:138-150. doi: 10.1016/j.yjmcc.2016.08.006. PubMed
PMID: 27515282.

Balogh E, Tóth A, Tolnai E, Bodó T, Bányai E, Szabó DJ, Petrovski G, Jeney V.
Osteogenic differentiation of human lens epithelial cells might contribute to
lens calcification. Biochim Biophys Acta. 2016 Sep;1862(9):1724-31. doi:
10.1016/j.bbadis.2016.06.012. PubMed PMID: 27318027.

Ivastinovic D, Schwab C, Mossböck G, Weger M, Pössl SL, Petrovski G, Wedrich
A, Velikay-Parel M. The configuration of the vitreomacular interface determines
the pattern of pseudophakic cystoid macular oedema. Acta Ophthalmol. 2016 May 26. doi: 10.1111/aos.13104. PubMed PMID: 27226394.

Veréb Z, Póliska S, Albert R, Olstad OK, Boratkó A, Csortos C, Moe MC, Facskó
A, Petrovski G. Role of Human Corneal Stroma-Derived Mesenchymal-Like Stem Cells in Corneal Immunity and Wound Healing. Sci Rep. 2016 May 19;6:26227. doi:
10.1038/srep26227. PubMed PMID: 27195722; PubMed Central PMCID: PMC4872602.

Koskela A, Reinisalo M, Petrovski G, Sinha D, Olmiere C, Karjalainen R,
Kaarniranta K. Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces
Autophagy in ARPE-19 Cells. Nutrients. 2016 May 11;8(5). pii: E284. doi:
10.3390/nu8050284. PubMed PMID: 27187449; PubMed Central PMCID: PMC4882697.

Eszes DJ, Szabó DJ, Russell G, Kirby P, Paulik E, Nagymajtényi L, Facskó A,
Moe MC, Petrovski BÉ. Diabetic Retinopathy Screening Using Telemedicine Tools:
Pilot Study in Hungary. J Diabetes Res. 2016;2016:4529824. doi:
10.1155/2016/4529824. PubMed PMID: 28078306; PubMed Central PMCID: PMC5204085.

Salvanos P, Moe MC, Utheim TP, Bragadóttir R, Kerty E. ULTRA-WIDE-FIELD FUNDUS IMAGING IN THE DIAGNOSIS AND FOLLOW-UP OF SUSAC SYNDROME. Retin Cases Brief Rep. 2016 Nov 8. PubMed PMID: 27828899.

Pathak M, Olstad OK, Drolsum L, Moe MC, Smorodinova N, Kalasova S, Jirsova K, Nicolaissen B, Noer A. The effect of culture medium and carrier on explant
culture of human limbal epithelium: A comparison of ultrastructure, keratin
profile and gene expression. Exp Eye Res. 2016 Dec;153:122-132. doi:
10.1016/j.exer.2016.09.012. PubMed PMID: 27702552.

Osnes-Ringen Ø, Berg KH, Moe MC, Zetterström C, Røger M, Nicolaissen B. Cell death pattern in lens epithelium of cataract patients. Acta Ophthalmol. 2016
Aug;94(5):514-20. doi: 10.1111/aos.13009. PubMed PMID: 27061232.

Skjellegrind HK, Fayzullin A, Johnsen EO, Eide L, Langmoen IA, Moe MC, Vik-Mo EO. Short-Term Differentiation of Glioblastoma Stem Cells Induces Hypoxia
Tolerance. Neurochem Res. 2016 Jul;41(7):1545-58. doi: 10.1007/s11064-016-1868-2. PubMed PMID: 26915110; PubMed Central PMCID: PMC4893075.

Holm KL, Indrevaer RL, Myklebust JH, Kolstad A, Moskaug JØ, Naderi EH, Blomhoff HK. Myeloid cell leukaemia 1 has a vital role in retinoic acid-mediated protection of Toll-like receptor 9-stimulated B cells from spontaneous and DNA damage-induced apoptosis. Immunology. 2016 Sep;149 (1):62-73.

Begic, Anadi; Isfoss, Björn L.; Lønnerød, Linn K.; Vigen, Alexander; Moskaug, Jan Ø. Survival and Inflammatory Response in Adipose-derived Mesenchymal Stem Cell-enriched Mouse Fat Grafts. Plastic and Reconstructive Surgery - Global Open . 4(12):e1110, December 2016.

Tekpli X, Urbanucci A, Hashim A, Vågbø CB, Lyle R, Kringen MK, Staff AC, Dybedal I, Mills IG, Klungland A, Staerk J. Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells. Epigenetics Chromatin. 2016 May 31;9:21.

Gamal W, Treskes P, Chesne CG, Samuel K, Sullivan GJ, Siller R, Srsen V, Underwood I, Smith S, Hayes PC, Plevris JN, Bagnaninchi PO and Nelson LJ. Low-dose acetaminophen disrupts cell-cell tight junctions in human hepatocytes and in vivo mouse liver. Scientific Reports. 2016:

Siller R, Naumovska E, Mathapati S, Lycke M and Sullivan GJ*. Development of a rapid screen for the endodermal differentiation potential of human pluripotent stem cell lines. Scientific Reports. 2016: DOI: 10.1038/srep37178. (*corresponding author).

Mathapati S, Siller R, Impellizzeri AR, Lycke M, Vegheim K, Almass R, Sullivan GJ*. Small molecule directed hepatocytes like cells differentiation of human pluripotent stem cells. Curr. Protoc. Stem Cell Biol. 2016: 38:1G.6.1-1G.6.18.doi: 10.1002/cpsc.13. (*corresponding author).

Xu M, Stattin E-L, Shaw G, Heinegård D, Sullivan G, Wilmut I, Colman A, Önnerfjord P, Khabut A, Aspberg A, Dockery P, Hardingham T, Murphy M, Barry F. Chondrocytes derived from mesenchymal stromal cells and induced pluripotent cells of patients with familial osteochondritis dissecans exhibit an ER stress response and defective matrix assembly. Stem Cells Transl. Med. 2016: 5:1171-1181.

Klungland A, Dahl JA, Greggains G, Fedorcsak P, Filipczyk A. Reversible RNA modifications in meiosis and pluripotency.Nat Methods. 2016 Dec 29;14(1):18-22. doi: 10.1038/nmeth.4111.

Feigelman J, Ganscha S, Hastreiter S, Schwarzfischer M, Filipczyk A, Schroeder T, Theis FJ, Marr C, Claassen M. Analysis of Cell Lineage Trees by Exact Bayesian Inference Identifies Negative Autoregulation of Nanog in Mouse Embryonic Stem Cells..Cell Syst. 2016 Nov 23;3(5):480-490.e13. doi: 10.1016/j.cels.2016.11.001.

Hoppe PS, Schwarzfischer M, Loeffler D, Kokkaliaris KD, Hilsenbeck O, Moritz N, Endele M, Filipczyk A, Gambardella A, Ahmed N, Etzrodt M, Coutu DL, Rieger MA, Marr C, Strasser MK, Schauberger B, Burtscher I, Ermakova O, Bürger A, Lickert H, Nerlov C, Theis FJ, Schroeder T. Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios. Nature. 2016 Jul 14;535(7611):299-302. doi: 10.1038/nature18320.

Hilsenbeck O, Schwarzfischer M, Skylaki S, Schauberger B, Hoppe PS, Loeffler D, Kokkaliaris KD, Hastreiter S, Skylaki E, Filipczyk A, Strasser M, Buggenthin F, Feigelman JS, Krumsiek J, van den Berg AJ, Endele M, Etzrodt M, Marr C, Theis FJ, Schroeder T. Software tools for single-cell tracking and quantification of cellular and molecular properties. Nat Biotechnol. 2016 Jul 12;34(7):703-6. doi: 10.1038/nbt.3626.

Hals IK, Ma Z, Singh R, Scholz H, Björklund A, Grill V. Culture at low glucose up-regulates mitochondrial function in pancreatic beta cells with accompanying effects on viability. Islets. 2016 Nov;8(6):165-176.

Halvorsen B, Santilli F*, Scholz H*, Saharoui A, Lattanzio, S, Formoso, G, Di Fulvio P, Kari Otterdal K, Gregersen I, Stavik B, Ueland T, Liani R, Davi G, Aukrust P. LIGHT/TNFSF14 is related to glycemic control in patients with type 2 diabetes mellitus and promotes endothelial cell inflammation and islet cell dysfunction in vitro. Diabetologia. 2016 Oct;59(10):2134-44. *co-Author

Kloster-Jensen K, Sahraoui A, Vethe NT, Bremer S, Korsgren O, Bergan S, Foss A, and Scholz H. Treatment with tacrolimus and sirolimus reveals no additional adverse effects on human islets in vitro compared to each drug alone but are reduced by adding glucocorticoids. J Diabetes Res. 2016;2016:4196460.